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Each peptide binds to a receptor on or inside a cell, initiating cascades like growth, repair, fat metabolism, inflammation regulation, or hormone signaling

(See 87 FR 44798 for a complete discussion of this requirement.) Parties may request an advisory opinion from CMS regarding whether a hospital is (or would be) the same hospital following the relocation of original operating rooms, procedure rooms, or beds to a location other than the main campus of a hospital

A combination may be considered in select cases, but only with medical supervision and ongoing monitoring

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